Recherche

Le service de neurochirurgie de Bicêtre a une expertise reconnue dans les pathologies de la moelle épinière et de la jonction craniovertébrale (malformation de Chiari, syringomyélie, tumeurs intramédullaires, méningiomes et schwannomes rachidiens).

Dans la continuité de notre expertise chirurgicale, nous animons et participons à divers projets de recherche fondamentale et clinique autour des pathologies médullaires.

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Projets de recherche en cours

Single-cell spinal cord atlas [sc2atlas] : caractérisation transcriptomique des populations neuronales de la moelle épinière chez la souris et chez l’homme.

Responsable : Dr Steven Knafo
Financement : NeuroSphinx
Collaboration avec l’institut des Neurosciences Paris-Saclay (NeuroPSI) et la plate-forme de séquence de l’institut de biologie intégrative de la cellule.

Exome sequencing in Chiari [ChiariGene] : recherche de mutations par séquençage en exome entier dans les cas familiaux de malformations de Chiari

Responsable : Dr Steven Knafo
Financement : association APAISER
Collaboration avec V. Capa et P. De Marco, Instituto Gaslini, Genova (Italy)

Hémangioblastomes et béta-bloquants : efficacité d’un traitement par béta-bloquants dans les hémangioblastomes du SNC en lien avec une maladie de VHL

Responsable : Pr Nozar Aghakhani
Financement : PHRC
Collaboration avec le centre PREDIR du Pr S. Richard

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Publications du service d’accueil (Neurochirurgie, Bicêtre, Pr Parker) – 2014-2020

Score SIGAPS = 739

Tuleasca, C ; Ducos, Y ; Knafo, S ; Levivier, M ; Aghakhani, N ; Parker, F , Surgery for cyst dilatation of a ventriculus terminalis in adults: keep it simple!, Neurochirurgie, 2020, ,

Yrondi, A ; Valton, L ; Bouilleret, V ; Aghakhani, N ; Curot, J ; Birmes, PJ , Post-traumatic Stress Disorder With Flashbacks of an Old Childhood Memory Triggered by Right Temporal Lobe Epilepsy Surgery in Adulthood., Front Psychiatry, 2020, 11, 351

Tuleasca, C ; Ducos, Y ; Leroy, HA ; Chanson, P ; Knafo, S ; Levivier, M & al , Transsphenoidal resection for pituitary adenoma in elderly versus younger patients: a systematic review and meta-analysis., Acta Neurochir (Wien), 2020, 162, 1297-1308

Pagiola, I ; Caroff, J ; Mihalea, C ; Aghakhani, N ; Ikka, L ; Chalumeau, V & al , Republished: Spinal arteriovenous malformation without endovascular arterial access: is a combined neurosurgical approach and direct venous puncture an option?, J Neurointerv Surg, 2020, 12, e4

Pagiola, I ; Caroff, J ; Mihalea, C ; Aghakhani, N ; Ikka, L ; Chalumeau, V & al , Spinal arteriovenous malformation without endovascular arterial access: is a combined neurosurgical approach and direct venous puncture an option?, BMJ Case Rep, 2020, 13,

Roux, A ; Pallud, J ; Saffroy, R ; Edjlali-Goujon, M ; Debily, MA ; Boddaert, N & al , High-grade gliomas in adolescents and young adults highlight histomolecular differences with their adult and paediatric counterparts., Neuro Oncol, 2020, ,

Tuleasca, C ; Ducos, Y ; David, P ; Aghakhani, N , Microsurgical resection of a radicular hemangioblastoma with subarachnoid hemorrhage: how I do it., Acta Neurochir (Wien), 2020, 162, 957-959

Tuleasca, C ; Al-Risi, AS ; David, P ; Adam, C ; Aghakhani, N ; Parker, F , Paragangliomas of the spine: a retrospective case series in a national reference French center., Acta Neurochir (Wien), 2020, 162, 831-837

Proust, F ; Bracard, S ; Thines, L ; Pelissou-Guyotat, I ; Leclerc, X ; Penchet, G & al , Functional outcome 1 year after aneurysmal subarachnoid hemorrhage due to ruptured intracranial aneurysm in elderly patients., Neurochirurgie, 2020, 66, 1-8

Caplain, S ; Chenuc, G ; Blancho, S ; Marque, S ; Aghakhani, N , Efficacy of Psychoeducation and Cognitive Rehabilitation After Mild Traumatic Brain Injury for Preventing Post-concussional Syndrome in Individuals With High Risk of Poor Prognosis: A Randomized Clinical Trial., Front Neurol, 2019, 10, 929

Tuleasca, C ; Ducos, Y ; Levivier, M ; Parker, F ; Aghakhani, N , Letter to the Editor. Arachnoid webs: preoperative differential diagnosis and surgical exploration., J Neurosurg Spine, 2019, , 1-2

Tuleasca, C ; Copaciu, R ; Aureli, V ; Aghakhani, N ; Parker, F ; Levivier, M , Delayed hearing loss after microvascular decompression for hemifacial spasm-an unsolved conspiracy of the cochlear apparatus., Acta Neurochir (Wien), 2019, 161, 1599-1601

Amelot, A ; Saliou, G ; Benichi, S ; Alias, Q ; Boulouis, G ; Zerah, M & al , Long-term Outcomes of Cerebral Aneurysms in Children., Pediatrics, 2019, 143,

Hage, M ; Chaligné, R ; Viengchareun, S ; Villa, C ; Salenave, S ; Bouligand, J & al , Hypermethylator Phenotype and Ectopic GIP Receptor in GNAS Mutation-Negative Somatotropinomas., J Clin Endocrinol Metab, 2019, 104, 1777-1787

Proust, F ; Bracard, S ; Lejeune, JP ; Thines, L ; Leclerc, X ; Penchet, G & al , A randomized controlled study assessing outcome, cognition, autonomy and quality of life in over 70-year-old patients after aneurysmal subarachnoid hemorrhage., Neurochirurgie, 2018, 64, 395-400

Brianza, L ; Parker, F ; Ratnam, N , [in process]., Krankenpfl Soins Infirm, 2017, 110, 68-69

Appay, R ; Tabouret, E ; Touat, M ; Carpentier, C ; Colin, C ; Ducray, F & al , Somatostatin receptor 2A protein expression characterizes anaplastic oligodendrogliomas with favorable outcome., Acta Neuropathol Commun, 2018, 6, 89

Rosenberg, S ; Ducray, F ; Alentorn, A ; Dehais, C ; Elarouci, N ; Kamoun, A & al , Machine Learning for Better Prognostic Stratification and Driver Gene Identification Using Somatic Copy Number Variations in Anaplastic Oligodendroglioma., Oncologist, 2018, 23, 1500-1510

Knafo, S ; Wyart, C , Active mechanosensory feedback during locomotion in the zebrafish spinal cord., Curr Opin Neurobiol, 2018, 52, 48-53

Appay, R ; Tabouret, E ; Macagno, N ; Touat, M ; Carpentier, C ; Colin, C & al , IDH2 mutations are commonly associated with 1p/19q codeletion in diffuse adult gliomas., Neuro Oncol, 2018, 20, 716-718

Hage, M ; Viengchareun, S ; Brunet, E ; Villa, C ; Pineau, D ; Bouligand, J & al , Genomic Alterations and Complex Subclonal Architecture in Sporadic GH-Secreting Pituitary Adenomas., J Clin Endocrinol Metab, 2018, 103, 1929-1939

Caplain, S ; Blancho, S ; Marque, S ; Montreuil, M ; Aghakhani, N , Early Detection of Poor Outcome after Mild Traumatic Brain Injury: Predictive Factors Using a Multidimensional Approach a Pilot Study., Front Neurol, 2017, 8, 666

Giammattei, L ; Borsotti, F ; Parker, F ; Messerer, M , Chiari I malformation: surgical technique, indications and limits., Acta Neurochir (Wien), 2018, 160, 213-217

Knafo, S ; Prendergast, A ; Thouvenin, O ; Figueiredo, SN ; Wyart, C , Bioluminescence Monitoring of Neuronal Activity in Freely Moving Zebrafish Larvae., Bio Protoc, 2017, 7, e2550

Parker, F , , Neurochirurgie, 2017, 63, 430-431

Parker, F , , Neurochirurgie, 2017, 63, 341-342

Knafo, S ; Mireau, E ; Bennis, S ; Baussart, B ; Aldea, S ; Gaillard, S , Operative and Perioperative Durations in O-Arm vs C-Arm Fluoroscopy for Lumbar Instrumentation., Oper Neurosurg (Hagerstown), 2018, 14, 273-278

Dupouy, J ; Ory-Magne, F ; Mekies, C ; Rousseau, V ; Puel, M ; Rerat, K & al , Cognitive complaint in early Parkinson”s disease: A pilot study., Acta Neurol Scand, 2018, 137, 59-66

Giammattei, L ; Messerer, M ; Daniel, RT ; Aghakhani, N ; Parker, F , Long term outcome of surgical treatment of Chiari Malformation without syringomyelia., J Neurosurg Sci, 2017, ,

Knafo, S ; Fidelin, K ; Prendergast, A ; Tseng, PB ; Parrin, A ; Dickey, C & al , Mechanosensory neurons control the timing of spinal microcircuit selection during locomotion., Elife, 2017, 6,

Campello, C ; Parker, F ; Slimani, S ; Le Floch, A ; Herbrecht, A ; Aghakhani, N & al , [Adult intramedullary gliomas]., Neurochirurgie, 2017, 63, 381-390

Caroff, J ; Benachour, N ; Ikka, L ; Nevoux, J ; Parker, F ; Da Ros, V & al , 3D-guided direct puncture therapeutic embolization of intracranial tumors., J Neurointerv Surg, 2017, 9, 787-791

Messerer, M ; Maduri, R ; Daniel, RT ; Parker, F , Surgery for intramedullary astrocytomas: does tumour location matter?, Acta Neurochir (Wien), 2017, 159, 937-938

Parker, F ; Campello, C ; Lejeune, JP ; David, P ; Herbrecht, A ; Aghakhani, N & al , [Intramedullary astrocytomas: A French retrospective multicenter study]., Neurochirurgie, 2017, 63, 402-409

Aghakhani, N ; Messerer, M ; David, P ; Herbrecht, A ; Parker, F , [Intramedullary ependymomas: A French retrospective multicenter study of 221 cases]., Neurochirurgie, 2017, 63, 391-397

Cossu, G ; Lacroix, C ; Adams, C ; Daniel, RT ; Parker, F ; Messerer, M , Neuroglial intramedullary tumors: The collaboration between neurosurgeons and neuropathologists., Neurochirurgie, 2017, 63, 413-418

Moreau, T ; Bungener, C ; Heinzlef, O ; Suchet, L ; Borgel, F ; Bourdeix, I & al , Anxiety and Coping Strategy Changes in Multiple Sclerosis Patients Initiating Fingolimod: The GRACE Prospective Study., Eur Neurol, 2017, 77, 47-55

Herbrecht, A ; Messerer, M ; Parker, F , Development of a lateralization index for intramedullary astrocytomas and ependymomas., Neurochirurgie, 2017, 63, 410-412

Bielle, F ; Ducray, F ; Mokhtari, K ; Dehais, C ; Adle-Biassette, H ; Carpentier, C & al , Tumor cells with neuronal intermediate progenitor features define a subgroup of 1p/19q co-deleted anaplastic gliomas., Brain Pathol, 2017, 27, 567-579

Messerer, M ; Richoz, B ; Cossu, G ; Dhermain, F ; Hottinger, AF ; Parker, F & al , Recent advances in the management of atypical meningiomas., Neurochirurgie, 2016, 62, 213-22

Carpentier, A ; Canney, M ; Vignot, A ; Reina, V ; Beccaria, K ; Horodyckid, C & al , Clinical trial of blood-brain barrier disruption by pulsed ultrasound., Sci Transl Med, 2016, 8, 343re2

Horodyckid, C ; Canney, M ; Vignot, A ; Boisgard, R ; Drier, A ; Huberfeld, G & al , Safe long-term repeated disruption of the blood-brain barrier using an implantable ultrasound device: a multiparametric study in a primate model., J Neurosurg, 2017, 126, 1351-1361

Knafo, S ; Messerer, M ; Court, C ; Parker, F , [Predictive factors of spinal deformity following surgery for intramedullary tumors]., Neurochirurgie, 2017, 63, 419-425

Giammattei, L ; Messerer, M ; Aghakhani, N ; David, P ; Herbrecht, A ; Richard, S & al , Surgical resection of medulla oblongata hemangioblastomas: outcome and complications., Acta Neurochir (Wien), 2016, 158, 1333-41

Giammattei, L ; Penet, N ; Parker, F ; Messerer, M , Intramedullary ependymoma: Microsurgical resection technique., Neurochirurgie, 2017, 63, 398-401

Kamoun, A ; Idbaih, A ; Dehais, C ; Elarouci, N ; Carpentier, C ; Letouzé, E & al , Integrated multi-omics analysis of oligodendroglial tumours identifies three subgroups of 1p/19q co-deleted gliomas., Nat Commun, 2016, 7, 11263

David, P ; Messerer, M ; Aghakhani, N ; Benoudiba, F ; Adam, C ; Richard, S & al , [Intramedullary hemangioblastomas]., Neurochirurgie, 2017, 63, 366-371

Berry-Kravis, E ; Des Portes, V ; Hagerman, R ; Jacquemont, S ; Charles, P ; Visootsak, J & al , Mavoglurant in fragile X syndrome: Results of two randomized, double-blind, placebo-controlled trials., Sci Transl Med, 2016, 8, 321ra5

Goldwirt, L ; Canney, M ; Horodyckid, C ; Poupon, J ; Mourah, S ; Vignot, A & al , Enhanced brain distribution of carboplatin in a primate model after blood-brain barrier disruption using an implantable ultrasound device., Cancer Chemother Pharmacol, 2016, 77, 211-6

Bah, AB ; N””dri, OD ; Herbrecht, A ; Parker, F , MALIGNANT TRANSFORMATION OF CRANIAL NERVE SCHWANNOMA AFTER RADIOSURGERY – CASE REPORT., J West Afr Coll Surg, 2014, 4, 112-20

Chandran, S ; Parker, F ; Lontos, S ; Vaughan, R ; Efthymiou, M , Can we ease the financial burden of colonoscopy? Using real-time endoscopic assessment of polyp histology to predict surveillance intervals., Intern Med J, 2015, 45, 1293-9

Alentorn, A ; Dehais, C ; Ducray, F ; Carpentier, C ; Mokhtari, K ; Figarella-Branger, D & al , Allelic loss of 9p21.3 is a prognostic factor in 1p/19q codeleted anaplastic gliomas., Neurology, 2015, 85, 1325-31

Simonin, A ; Levivier, M ; Bloch, J ; Messerer, M , Cranial nerve palsies after shunting of an isolated fourth ventricle., BMJ Case Rep, 2015, 2015,

Cossu, G ; Levivier, M ; Daniel, RT ; Messerer, M , The Role of Mifepristone in Meningiomas Management: A Systematic Review of the Literature., Biomed Res Int, 2015, 2015, 267831

Labreche, K ; Simeonova, I ; Kamoun, A ; Gleize, V ; Chubb, D ; Letouzé, E & al , TCF12 is mutated in anaplastic oligodendroglioma., Nat Commun, 2015, 6, 7207

Desnos-Ollivier, M ; Patel, S ; Raoux-Barbot, D ; Heitman, J ; Dromer, F , Cryptococcosis Serotypes Impact Outcome and Provide Evidence of Cryptococcus neoformans Speciation., mBio, 2015, 6, e00311

Rerat, K ; Parker, F ; Nasser, G ; Vidaud, D ; Riant, F ; Tournier-Lasserve, E & al , Occurrence of multiple Cerebral Cavernous Malformations in a patient with Neurofibromatosis type 1., J Neurol Sci, 2015, 350, 98-100

Messerer, M ; Cossu, G ; Daniel, RT ; Jouanneau, E , Letter to the editor: Knosp Grades 2-3 nonfunctioning pituitary adenomas., J Neurosurg, 2015, 122, 986-7

Lebuhn, G ; Droege, S ; Connor, EF ; Gemmill-Herren, B ; Potts, SG ; Minckley, RL & al , Evidence-based conservation: reply to Tepedino et al., Conserv Biol, 2015, 29, 283-5

Zaldivar-Jolissaint, JF ; Messerer, M ; Bervini, D ; Mosimann, PJ ; Levivier, M ; Daniel, RT , Rupture of a concealed aneurysm after intravenous thrombolysis of a thrombus in the parent middle cerebral artery., J Stroke Cerebrovasc Dis, 2015, 24, e63-5

Chandran, S ; Parker, F ; Vaughan, R ; Mitchell, B ; Fanning, S ; Brown, G & al , Right-sided adenoma detection with retroflexion versus forward-view colonoscopy., Gastrointest Endosc, 2015, 81, 608-13

Figarella-Branger, D ; Mokhtari, K ; Colin, C ; Uro-Coste, E ; Jouvet, A ; Dehais, C & al , Prognostic Relevance of Histomolecular Classification of Diffuse Adult High-Grade Gliomas with Necrosis., Brain Pathol, 2015, 25, 418-28

Lipcsey, M ; McNicol, L ; Parker, F ; Poustie, S ; Liu, G ; Uchino, S & al , Effect of perfusion pressure on the splanchnic circulation after CPB: a pilot study., Minerva Anestesiol, 2015, 81, 752-64

Chibbaro, S ; Gory, B ; Marsella, M ; Tigan, L ; Herbrecht, A ; Orabi, M & al , Surgical management of spinal dural arteriovenous fistulas., J Clin Neurosci, 2015, 22, 180-3

Messerer, M ; Dubourg, J , Endoscopic pituitary surgery., J Neurosurg, 2014, 121, 1533

Graham, J ; Sidebotham, D ; Story, DA ; Hu, R ; Parker, F , Adequate images in intraoperative transoesophageal echocardiography: a quality improvement project., Anaesth Intensive Care, 2014, 42, 640-8

Jouanneau, E ; Simon, E ; Jacquesson, T ; Sindou, M ; Tringali, S ; Messerer, M & al , The endoscopic endonasal approach to the Meckel”s cave tumors: surgical technique and indications., World Neurosurg, 2014, 82, S155-61

Cossu, G ; Farhane, MA ; Daniel, RT ; Messerer, M , Spinal epidural abscess from group A Streptococcus after varicella infection: a case report and review of the literature., Childs Nerv Syst, 2014, 30, 2129-33

Knafo, S ; Court, C ; Parker, F , Predicting sagittal deformity after surgery for intramedullary tumors., J Neurosurg Spine, 2014, 21, 342-7

Cossu, G ; Messerer, M ; Oddo, M ; Daniel, RT , To look beyond vasospasm in aneurysmal subarachnoid haemorrhage., Biomed Res Int, 2014, 2014, 628597

Cossu, G ; Messerer, M ; Daniel, RT ; Diserens, K , Diagnostic dyspraxia by disrupted fiber connections of the posterior corpus callosum after distal anterior cerebral artery aneurysm rupture., Acta Neurochir (Wien), 2014, 156, 1327-8

Figarella-Branger, D ; Mokhtari, K ; Dehais, C ; Jouvet, A ; Uro-Coste, E ; Colin, C & al , Mitotic index, microvascular proliferation, and necrosis define 3 groups of 1p/19q codeleted anaplastic oligodendrogliomas associated with different genomic alterations., Neuro Oncol, 2014, 16, 1244-54

McMillan, LR ; Parker, F ; Sport, A , Decisions, decisions! E-portfolio as an effective hiring assessment tool., Nurs Manage, 2014, 45, 52-4

Derrey, S ; Penchet, G ; Thines, L ; Lonjon, M ; David, P ; Bataille, B & al , French collaborative group series on giant intracranial aneurysms: Current management., Neurochirurgie, 2015, 61, 371-7

Dodd, NS ; Lord, JS ; Jehle, R ; Parker, S ; Parker, F ; Brooks, DR & al , Toxoplasma gondii: prevalence in species and genotypes of British bats (Pipistrellus pipistrellus and P. pygmaeus)., Exp Parasitol, 2014, 139, 6-11

Bouzat, P ; Sala, N ; Suys, T ; Zerlauth, JB ; Marques-Vidal, P ; Feihl, F & al , Cerebral metabolic effects of exogenous lactate supplementation on the injured human brain., Intensive Care Med, 2014, 40, 412-21

Mathon, B ; Ducros, A ; Bresson, D ; Herbrecht, A ; Mirone, G ; Houdart, E & al , Subarachnoid and intra-cerebral hemorrhage in young adults: rare and underdiagnosed., Rev Neurol (Paris), 2014, 170, 110-8

Zemmoura, I ; Vourc””h, P ; Paubel, A ; Parfait, B ; Cohen, J ; Bilan, F & al , A deletion causing NF2 exon 9 skipping is associated with familial autosomal dominant intramedullary ependymoma., Neuro Oncol, 2014, 16, 250-5

Reyes-Botero, G ; Dehais, C ; Idbaih, A ; Martin-Duverneuil, N ; Lahutte, M ; Carpentier, C & al , Contrast enhancement in 1p/19q-codeleted anaplastic oligodendrogliomas is associated with 9p loss, genomic instability, and angiogenic gene expression., Neuro Oncol, 2014, 16, 662-70

Chandran, S ; Parker, F ; Vaughan, R ; Efthymiou, M , The current practice standard for colonoscopy in Australia., Gastrointest Endosc, 2014, 79, 473-9

Yamgoue Tchameni, YT ; Messerer, M ; Zerlauth, JB ; Levivier, M ; Daniel, RT , Isolated developmental venous anomaly of the pons with transpontine drainage: case report., Clin Neuroradiol, 2014, 24, 77-81